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CO2 monitoring of MND patients at the Royal Preston Hospital

TCM5 BASIC chosen as a non-invasive method to monitor respiratory disease progression in MND patients

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The Lancashire and South Cumbria Motor Neurone Disease (MND) Care and Research Centre, part of the Royal Preston Hospital in the UK, provides holistic and multidisciplinary care to patients with MND.


Inaugurated in 1993, the Centre has a long track record of delivering high quality clinical research. Choosing Radiometer's TCM5 BASIC to monitor respiratory disease progress in MND patients lead to earlier conversations about patient treatment and improved quality of care.

The team from the Royal Preston HospitalThe team from the Royal Preston Hospital
The team at the Lancashire and South Cumbria MND Care and Research Centre

Monitoring disease progression is a big part of our role. It helps us make decisions early on and involve patients in the care decision making process.

- Pauline Callagher, Specialist Nurse

Monitoring carbon dioxide levels

Along with all other muscles in the body, MND can weaken the muscles that help your lungs inflate and deflate.

Before the TCM5 BASIC, the nurses at the Centre would “frequently have to wake patients up and quickly draw blood to be sent off to the lab for blood gas analysis. Now the TCM5 BASIC provides a full overnight trace of the blood gas levels of a patient,” explains physiotherapist Tracey McDonald.

Overnight monitoring

The TCM5 BASIC has a dedicated sleep mode and optional dark screen that makes it particularly suited to overnight monitoring – meaning patients can sleep undisturbed, helping to obtain accurate measurements.

It is well recognised that patients with MND experience progressive hypoventilation…. Patients in our Centre have access to nocturnal capnography and this allows us to assess nocturnal hypoventilation and thereby facilitate provision of timeline and optimal care.

- Professor Suresh Chhetri, Consultant Neurologist, Lancashire Teaching Hospitals NHS Foundation Trust

Getting the timing right

Because MND is a complex disease that can progress at different rates, the team place a strong emphasis on personalised care. When people living with MND begin to experience respiratory muscle weakness, there is a need to discuss available ventilator options with them.

“The TCM5 BASIC adds information about the right timing of when we need to be talking about whether the patient wants to be ventilated, whether they need someone to sit with them all night or whether they need to go into 24 hour-care,” explains McDonald.

A monitoring system tailored to the needs of a multidisciplinary care team

Having played an active part in developing the original NICE guidelines in 2010, specialist nurse Pauline Gallagher listened to respiratory consultants advocating for the use of transcutaneous monitoring to follow respiratory disease progression.

About the hospital

  • The Lancashire and South Cumbria MND Care and Research Centre serves an approximate population of 1.6 million in Lancashire and South Cumbria
  • The Centre was one of the first established MNC Care and Research Centres
  • The Centre participates in a number of multicentre research studies and clinical trials
  • The Centre is supported by the Sydney Driscoll Neuroscience Foundation and George Barton Motor Neurone Disease Trust

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Effective Date January 20th, 2023 (last updated January 20th, 2023)

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