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ABL80 FLEX CO-OX blood gas analyzer

High-quality co-oximetry in a portable device with automatic quality control

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  • Co-oximetry
  • Automatic Quality Control
  • Measures on battery

The ABL80 FLEX CO-OX blood gas analyzer provides blood gas, electrolytes, glucose and CO-oximetry parameters with all the advantages of a compact system, including simplicity and reliability.

Automatic quality control ensures reliability of testing performed at the point of care and documents regulatory compliance.

The ABL80 FLEX CO-OX analyzer comes with a variety of parameter panels and rapid start-up time after change of consumables. On top, it features customizable interface profiles and centralized user management, providing high flexibility to both laboratory and clinical staff.

Parameters measured

Blood gases: 
pH

Potential of hydrogen

The degree of acidity or alkalinity of any liquid (including blood) is a function of its hydrogen ion concentration [H+], and pH is simply a way of expressing hydrogen ion activity. The relationship between pH and hydrogen ion concentration is described thus:

pH = -log aH+
where aH+ is hydrogen ion activity.

Low pH is associated with acidosis and high pH with alkalosis [1,2].

Read more

The pH parameter is measured on these ABL blood gas analyzers:

  1. CLSI. Blood gas and pH analysis and related measurements; Approved Guidelines. CLSI document CA46-A2, 29, 8. Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2009
  2. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook
, pCO2

Partial pressure of carbon dioxide

Carbon dioxide (CO2) is an acidic gas; the amount of CO2 in blood is largely controlled by the rate and depth of breathing or ventilation. pCO2 is the partial pressure of CO2 in blood. It is a measure of the pressure exerted by that small portion (~5 %) of total CO2 that remains in the gaseous state, dissolved in the blood plasma. pCO2 is the respiratory component of acid-base balance and reflects the adequacy of pulmonary ventilation. The severity of ventilator failure as well as the chronicity can be judged by the accompanying changes in acid-base status [1,2].

Read more

The pCO2 parameter is measured on these ABL blood gas analyzers:


  1. Higgins C. Parameters that reflect the carbon dioxide content of blood. www.acutecaretesting.org Oct 2008.
  2. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014
, pO2

Partial pressure of oxygen

The amount of oxygen in blood is controlled by many variables, e.g. ventilation/perfusion. pO2 is the partial pressure of oxygen in a gas phase in equilibrium with the blood. pO2 only reflects a small fraction (1 – 2 %) of total oxygen in blood that is dissolved in blood plasma [1]. The remaining 98 – 99 % of oxygen present in blood is bound to the hemoglobin in the erythrocytes. pO2 primarily reflects the oxygen uptake in the lungs. [2]

Read more

The pO2 parameter is measured on these ABL blood gas analyzers:


1. Wettstein R, Wilkins R. Interpretation of blood gases. In: Clinical assessment in respiratory care, 6th ed. St. Louis: Mosby, 2010.
2. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.

Metabolites: 
cGlu

Glucose

Glucose, the most abundant carbohydrate in human metabolism, serves as the major intracellular energy source (see lactate). Glucose is derived principally from dietary carbohydrate, but it is also produced – primarily in the liver and kidneys – via the anabolic process of gluconeogenesis, and from the breakdown of glycogen (glycogenolysis). This endogenously produced glucose helps keep blood glucose concentration within normal limits, when dietary-derived glucose is not available, e.g. between meals or during periods of starvation. [1]

Read more

The cGlu parameter is measured on these ABL blood gas analyzers:


1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.

Electrolytes: 
cCa2+

Calcium

The calcium ion (Ca2+) is one of the most prevalent cations in the body, where approximately 1 % is present in the extracellular fluid of blood. Ca2+ plays a vital role for bone mineralization and many cellular processes, e.g. contractility of the heart and the skeletal musculature, neuromuscular transmission, hormone secretion and action in various enzymatic reactions such as, e.g. blood coagulation. [1]

Read more

The cCa2+ parameter is measured on these ABL blood gas analyzers:


1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.

, cCl-

Chloride

Chloride (Cl-) is the major anion in the extracellular fluid and one of the most important anions in blood. The main function of Cl- is to maintain osmotic pressure, fluid balance, muscular activity, ionic neutrality in plasma, and help elucidate the cause of acid-base disturbances. [1]

Read more

The cCl- parameter is measured on these ABL blood gas analyzers:


1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.

, cK+

Potassium

Potassium (K+) is the major cation in the intracellular fluid, where it has a 25 - 37-fold higher concentration (∼150 mmol/L in tissue cells, ∼105 mmol/L in erythrocytes) than in the extracellular fluid (∼4 mmol/L) [1, 2]. K+ has several vital functions in the body, e.g. regulation of neuromuscular excitability, regulation of heart rhythm, regulation of intracellular and extracellular volume and acid-base status. [3]

Read more

The cK+ parameter is measured on these ABL blood gas analyzers:


1. Burtis CA, Ashwood ER, Bruns DE. Tietz textbook of clinical chemistry and molecular diagnostics. 5th ed. St. Louis: Saunders Elsevier, 2012.
2. Engquist A. Fluids/Electrolytes/Nutrition. 1st ed. Copenhagen: Munksgaard, 1985.
3. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.

, cNa+

Sodium

Sodium (Na+) is the dominant cation in the extracellular fluid, where it has a 14-fold higher concentration (∼140 mmol/L) than in the intracellular fluid (∼10 mmol/L). Na+ is a major contributor of the osmolality of the extracellular fluid and its main function is largely in controlling and regulating water balance, and maintaining blood pressure. Na+ is also important for transmitting nerve impulses and activating muscle concretion. [1]

Read more

The cNa+ parameter is measured on these ABL blood gas analyzers:


1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.

Oximetry: 
ctHb

Total hemoglobin

The concentration of total hemoglobin (ctHb) in blood includes oxyhemoglobin (cO2Hb), deoxyhemoglobin (cHHb), as well as the dysfunctional hemoglobin species that are incapable of binding oxygen:

carboxyhemoglobin (cCOHb) (see COHb), methemoglobin (cMetHb) (see MetHb) and sulfhemoglobin (cSulfHb).

Thus:

ctHb = cO2Hb + cHHb + cCOHb + cMetHb + cSulfHb

The rare sulfHb is not included in the reported c tHb in most oximeters. [1]

Read more

The ctHb parameter is measured on these ABL blood gas analyzers:


1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.

, sO2

Oxygen saturation

Oxygen saturation (sO2) is the ratio of oxyhemoglobin concentration to concentration of functional hemoglobin (i.e. oxyhemoglobin (O2Hb) and deoxyhemoglobin (HHb) capable of carrying oxygen [1].

The sO2 reflects utilization of the currently available oxygen transport capacity. In arterial blood 98 – 99 % of oxygen is transported in erythrocytes bound to hemoglobin. The remaining 1–2 % of the oxygen transported in blood is dissolved in the blood plasma – this is the portion reported as partial pressure of oxygen (pO2) [2,3].

Read more

The sO2 parameter is measured on these ABL blood gas analyzers:


1. CLSI. Blood gas and pH analysis and related measurements; Approved Guidelines. CLSI document CA46-A2, 29, 8. Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2009.
2. Higgins C. Parameters that reflect the carbon dioxide content of blood. www.acutecaretesting.org Oct 2008.
3. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.

, FO2Hb

Fraction of oxyhemoglobin

FO2Hb in total hemoglobin in blood. [1]

Read more

The FO2Hb parameter is measured on these ABL blood gas analyzers:


1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.

, FCOHb

Carboxyhemoglobin

FCOHb is the fraction of total hemoglobin (ctHb) which is present as carboxyhemoglobin (COHb). By convention the fraction is expressed as a percentage (%).

In the range of 0 – 60 % COHb in arterial (COHb(a)) and venous blood (COHb(v)) is similar, i.e. either venous or arterial blood may be analyzed [1]. In most medical texts FCOHb(a) is referred to as simply COHb. [2]

Read more

The COHb parameter is measured on these ABL blood gas analyzers:


1. Lopez DM, Weingarten-Arams JS, Singer LP, Conway EE Jr. Relationship between arterial, mixed venous and internal jugular carboxyhemoglobin concentrations at low, medium and high concentrations in a piglet model of carbon monoxide toxicity. Crit Care Med 2000; 28: 1998-2001.
2. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on /en/knowledge-center/handbooks/acute-care-testing-handbook.

, FMetHb

Metahemoglobin

FMetHb is the fraction of total hemoglobin (ctHb) that is present as methemoglobin (MetHb). By convention the fraction is expressed as a percentage (%) [1]. In most medical text boxes MetHb(a) is referred to as simply methemoglobin (MetHb). [2]

Read more

The MetHb parameter is measured on these ABL blood gas analyzers:


1. CLSI. Blood gas and pH analysis and related measurements; Approved Guidelines. CLSI document CA46-A2, 29, 8. Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2009.
2. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.

, FHHb

Fraction of deoxyhemoglobin

FHHb in total hemoglobin in blood. [1]

1. Acute care testing handbook. Radiometer Medical ApS, 2700 Brønshøj, Denmark, 2014. As accessed on https://www.radiometer.com/en/knowledge-center/handbooks/acute-care-testing-handbook.

1st Automatic

The ABL80 FLEX CO-OX analyzer offers full IT connectivity to the AQURE point-of-care management system*), and can be used as a part of Radiometer’s 1st Automatic solution. 

*) In the USA, the remote control functionality of the AQURE system is not yet released for sale

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Effective Date January 20th, 2023 (last updated January 20th, 2023)

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